讲座报告

11月01日08:00 柯衡明:Advances in targeting cyclic nucleotide phosphodiesterases

讲座编号:jz-yjsb-2017-y071

讲座题目:Advances in targeting cyclic nucleotide phosphodiesterases

主 讲 人:柯衡明 教授 The University of North Carolina at Chapel Hill

讲座时间:20171101日(周三)上午0800

讲座地点:阜成路西校区教三332

参加对象:食品学院全体师生,及全校对专题感兴趣的师生

主办单位:研究生院

承办单位:食品学院

主讲人简介:

柯衡明博士是美国北卡莱罗纳大学教堂山分校医学院的终身教授。在哈佛大学攻读博士期间,师从William N. Lipscomb 教授(1976年诺贝尔化学奖获得者),在结构生物学研究方面取得了世界知名的成果,已经解出了PDE10类蛋白质的晶体结构。在CellScienceNature Struct. Biol.Proc Natl Acad Sci U S A J Biol ChemJ Med Chem.DevelopmentBiochem. Pharmacol.Biochem J., J. Mol. Biol.等国际著名学术期刊上发表论文80余篇。是American Crystallographic AssociationAmerican Association for the Advancement of Science委员,J. Biological Sciences, Current Bioactive Compounds 编委,以及Proc. Natl. Acad. Sci., J. Mol. Biol.,J. Biol. Chem.EMBO J.BiochemistryStructureProtein: structure, function and geneticsNature Structural Biology等顶级期刊的审稿人。

主讲内容:

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP  and cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides, their signalling pathways and, consequently, myriad biological responses in health and disease. Currently, a small number of PDE inhibitors are used clinically for treating the pathophysiological dysregulation of cyclic nucleotide signalling in several disorders, including erectile dysfunction, pulmonary hypertension, acute refractory cardiac failure, intermittent claudication and chronic obstructive pulmonary disease.

 


来源:研究生院(党委研究生工作部)    发表日期:2017-10-31    阅读次数: